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Quantitation of Hepcidin in Human Urine by Liquid Chromatography–mass Spectrometry by Sukhvinder S. Bansal; John M. Halket; Adrian Bomford; Robert J. Simpson; Nisha Vasavda; Swee Lay Thein; Robert C. Hider is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Quantitation of Hepcidin in Human Urine by Liquid Chromatography–mass Spectrometry about?
Hep ci din, a pep tide hor mone that is pro duced pre dom i nantly by hepa to cytes, has a major role in main tain ing iron homeo sta sis in mam mals. It acts as a neg a tive reg u la tor of iron entry into the sys temic cir cu la tion from mac ro phages and duo de nal en tero cytes, and it pro vides the principle to avoid repetition mech a nism for con trol ling plasma iron lev els [1]. Hep ci din was orig i nally iden ti fied by two groups as a liverinduced anti mi cro bial pep tide (LEAP-1) [2] and as a uri nary antimi cro bial pep tide (HAMP) [3]. Hep ci din is syn the sized in the liver as the 60-res i due pro-hep ci din but is largely pres ent in serum and urine in the form of the 25-res i due pep tide, which con tains 8 cys teine res i dues, con strained by four disul fide bridges. The orig i nally pro posed disul fide con nec tiv i ties 1-4, 2-8, 3-7, and 5-6 [3], based on the cys teine knot anti mi cro bial pep tides, were later revised [4] as a result of detailed struc tural stud ies to 1-8, 2-7, 3-6, and 4-5. This struc ture results in a dis torted b-sheet with a hair pin loop, sta bi lized by disul fide pair ing and hydro gen bonds, giv ing rise to an amphi pathic struc
Who reads Quantitation of Hepcidin in Human Urine by Liquid Chromatography–mass Spectrometry?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sukhvinder S. Bansal; John M. Halket; Adrian Bomford; Robert J. Simpson; Nisha Vasavda; Swee Lay Thein; Robert C. Hider
- Publisher
- Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0003-2697)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)