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What is Tumor One-Carbon Flux and Folate Dependence about?

The article discusses how tumor reliance on cytosolic versus mitochondrial one-carbon (1C) flux is influenced by folate availability, specifically through the expression of SLC19A1. It reveals that under physiological folate levels, many cancer cells primarily utilize cytosolic serine-hydroxymethyltransferase (SHMT1) for 1C unit production, suggesting SHMT1 as a potential anti-cancer drug target. The findings indicate that SLC19A1 expression can serve as a biomarker for identifying tumors that are more depe

Author

mautamphamngoc

Language

EN