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Metabolites and Diabetes Remission After Weight Loss by Kwee, Lydia Coulter (author);Ilkayeva, Olga (author);Muehlbauer, Michael J. (author);Bihlmeyer, Nathan (author);Wolfe, Bruce (author);Purnell, Jonathan Q. (author);Xavier Pi-Sunyer, F. (author);Chen, Haiying (author);Bahnson, Judy (author);Newgard, Christopher B. (author);Shah, Svati H. (author);Laferrère, Blandine (author) is a Medicine article available to read on EtoBox.

What is Metabolites and Diabetes Remission After Weight Loss about?

## Abstract There is marked heterogeneity in the response to weight loss interventions with regards to weight loss amount and metabolic improvement. We sought to identify biomarkers predictive of type 2 diabetes remission and amount of weight loss in individuals with severe obesity enrolled in the Longitudinal Assessment of Bariatric Surgery (LABS) and the Look AHEAD (Action for Health in Diabetes) studies. Targeted mass spectrometry-based profiling of 135 metabolites was performed in pre-intervention blood samples using a nested design for diabetes remission over five years (n = 93 LABS, n = 80 Look AHEAD; n = 87 remitters), and for extremes of weight loss at five years (n = 151 LABS; n = 75 with high weight loss). Principal components analysis (PCA) was used for dimensionality reduction, with PCA-derived metabolite factors tested for association with both diabetes remission and weight loss. Metabolic markers were tested for incremental improvement to clinical models, including the DiaRem score. Two metabolite factors were associated with diabetes remission: one primarily composed of branched chain amino acids (BCAA) and tyrosine (odds ratio (95% confidence interval) [OR (95% CI)]

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Author
Kwee, Lydia Coulter (author);Ilkayeva, Olga (author);Muehlbauer, Michael J. (author);Bihlmeyer, Nathan (author);Wolfe, Bruce (author);Purnell, Jonathan Q. (author);Xavier Pi-Sunyer, F. (author);Chen, Haiying (author);Bahnson, Judy (author);Newgard, Christopher B. (author);Shah, Svati H. (author);Laferrère, Blandine (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN
Field
Medicine (Health Sciences)

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