About this document
Sulfamate Acetamides As Self Immolative Electrophiles For Covalent Ligand Directed Release Chemistry by neetjeeug is a document available to read on EtoBox.
The article discusses the development of sulfamate acetamides as novel electrophiles for covalent ligand-directed release (CoLDR) chemistry, which are less reactive than traditional chloroacetamides while maintaining similar geometry. These compounds demonstrated effective labeling in protein assays and showed potential for in vivo applications, particularly in the context of BTK inhibitors like ibrutinib. The study highlights the tunable reactivity and stability of sulfamate acetamides, making them promisi
- Author
- neetjeeug
- Language
- EN