Opening book details…
Can I read Distinct Cellular Interactions of Secreted and Transmembrane Ebola Virus Glycoproteins on EtoBox?
Distinct Cellular Interactions of Secreted and Transmembrane Ebola Virus Glycoproteins by Zhi-yong Yang; Rafael Delgado; Ling Xu; Robert F. Todd; Elizabeth G. Nabel; Anthony Sanchez; Gary J. Nabel is a Medicine article available to read on EtoBox.
What is Distinct Cellular Interactions of Secreted and Transmembrane Ebola Virus Glycoproteins about?
The mechanisms by which Ebola virus evades detection and infects cells to cause hemorrhagic fever have not been defined, though its glycoprotein, synthesized in either a secreted or transmembrane form, is likely involved. Here the secreted glycoprotein was found to interact with neutrophils through CD16b, the neutrophil-specific form of the Fc γ receptor III, whereas the transmembrane glycoprotein was found to interact with endothelial cells but not neutrophils. A murine retroviral vector pseudotyped with the transmembrane glycoprotein preferentially infected endothelial cells. Thus, the secreted glycoprotein inhibits early neutrophil activation, which likely affects the host response to infection, whereas binding of the transmembrane glycoprotein to endothelial cells may contribute to the hemorrhagic symptoms of this disease.
Who reads Distinct Cellular Interactions of Secreted and Transmembrane Ebola Virus Glycoproteins?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Zhi-yong Yang; Rafael Delgado; Ling Xu; Robert F. Todd; Elizabeth G. Nabel; Anthony Sanchez; Gary J. Nabel
- Publisher
- American Association for the Advancement of Science (AAAS)
- Published
- 1998
- Language
- EN
- Field
- Medicine (Social Sciences)