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The Role of Tobacco Smoke in Bladder and Kidney Carcinogenesis: A Comparison of Exposures and Meta-analysis of Incidence and Mortality Risks by Marcus G. Cumberbatch; Matteo Rota; James W.F. Catto; Carlo La Vecchia is a Medicine article available to read on EtoBox.

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## Context: Tobacco smoke includes a mix of carcinogens implicated in the etiology of bladder cancer (bc) and renal cell cancer (rcc). ## Objective: We reviewed the impact of tobacco exposure on bcc and rcc incidence and mortality, and whether smoking cessation decreases the risk. ## Evidence acquisition: A systematic review of original articles in english was performed in august 2013. meta-analysis of risks was performed using adjusted risk ratios where available. publication bias was assessed using begg and egger tests. ## Evidence synthesis: We identified 2683 papers, of which 107 fulfilled our inclusion criteria, of which 83 studies investigated bc and 24 investigated rcc. the pooled relative risk (rr) of bc incidence was 2.58 (95% confidence interval [ci] 2.37-2.80) for all smokers, 3.47 (3.07-3.91) for current smokers, and 2.04 (1.85-2.25) for former smokers. the corresponding pooled rr of bc disease-specific mortality (dsm) was 1.47 (1.24-1.75), 1.53 (1.12-2.09) and 1.44 (0.99-2.11). the pooled rr of rcc incidence was 1.31 (1.22-1.40) for all smokers, 1.36 (1.19-1.56) for current smokers, and 1.16 (1.08-1.25) for former smokers. the corresponding rcc dsm risk was 1.23 (1.08-

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Author

Marcus G. Cumberbatch; Matteo Rota; James W.F. Catto; Carlo La Vecchia

Published

2015

Language

EN

Field

Medicine (Health Sciences)