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Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury by Zahid N. Rabbani; Ines Batinic-Haberle; Mitchell S. Anscher; Jie Huang; Brian J. Day; Elaine Alexander; Mark W. Dewhirst; Zeljko Vujaskovic is a Medicine article available to read on EtoBox.

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## Purpose: To determine whether administration of a catalytic antioxidant, mn(iii) tetrakis(n,n'-diethylimidazolium-2-yl) porphyrin, aeol 10150, with superoxide dismutase (sod) mimetic properties, reduces the severity of radiation-induced injury to the lung from single-dose irradiation (rt) of 28 gy. ## Methods and materials: Rats were randomly divided into four different dose groups (0, 1, 10, and 30 mg/kg/day of aeol 10150), receiving either short-term (1 week) or long-term (10 weeks) drug administration via osmotic pumps. rats received single-dose irradiation (rt) of 28 gy to the right hemithorax. breathing rates, body weights, blood samples, histopathology, and immunohistochemistry were used to assess lung damage. ## Results: There was no significant difference in any of the study endpoints between the irradiated controls and the three groups receiving rt and short-term administration of aeol 10150. for the long-term administration, functional determinants of lung damage 20 weeks postradiation were significantly worse for rt + phosphate-buffered saline (pbs) and rt + 1 mg/kg/day of aeol 10150 as compared with the irradiated groups treated with higher doses of aeol 10150 (10 or

Who reads Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury?

Author

Zahid N. Rabbani; Ines Batinic-Haberle; Mitchell S. Anscher; Jie Huang; Brian J. Day; Elaine Alexander; Mark W. Dewhirst; Zeljko Vujaskovic

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2007

Language

EN

Field

Medicine (Health Sciences)