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Regiospecific addition of Grignard reagents to the 4-position of activated imidazo[4,5-c]pyridine. A convenient method for the synthesis of 4-alkyl by Ish K. Khanna; Richard M. Weier is a Chemistry article available to read on EtoBox.
What is Regiospecific addition of Grignard reagents to the 4-position of activated imidazo[4,5-c]pyridine. A convenient method for the synthesis of 4-alkyl about?
## Tht addition of Grignard reagents IO 5-acyknidawpyridiniam salts gives I-sabstituted S-acyMSdihydroimidazopyridines. This reaction was atilized to ~~A~sise I-sabstitated (methyl, t-batyl & phenyl) imidozopyridincs. During the cour8e of our investigation8 on a 8cde8 of antagonists of Platelet Activating Factor (PAF)l, it was necessary to synthesize 4-substituted (alkyl8c aryl) imi~4,5~]pyridines. A search of the literature revealed only the 4-methyl analog 2 which had been synthesized2 by a circuitous route starting with Camine 2methylpyridine. As a general approach, this method was unattractive because of the lack of literatum on appropriately substituted 3&diaminopyridines. Theteftne, an alternate general method, preferably from a convergent intermediate was sought.
Who reads Regiospecific addition of Grignard reagents to the 4-position of activated imidazo[4,5-c]pyridine. A convenient method for the synthesis of 4-alkyl?
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- Author
- Ish K. Khanna; Richard M. Weier
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)
- Published
- 1993
- Language
- EN
- Field
- Chemistry (Physical Sciences)