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A role for surfactant protein D in innate immunity of the human prostate by Rebecca E. Oberley; Kelli L. Goss; Laila Dahmoush; Kevin A. Ault; Erika C. Crouch; Jeanne M. Snyder is a Medicine article available to read on EtoBox.

What is A role for surfactant protein D in innate immunity of the human prostate about?

## Abstract ## OBJECTIVES Surfactant protein D (SP‐D) is a member of the collectin family of proteins, which are involved in host defense mechanisms in the lung. In the present study, we found that SP‐D is produced in the human prostate where it may play a role in innate immunity. ## METHODS AND RESULTS Using reverse‐transcriptase PCR and Western blot analysis, we demonstrate that SP‐D mRNA and protein are present in human prostate tissue. In situ hybridization and immunohistochemistry revealed that SP‐D mRNA and protein are localized in epithelial cells of prostate glands. Prostate glands that are surrounded by inflammatory cells produce increased amounts of SP‐D protein. We also show that SP‐D inhibits the infection of LNCaP and P69SV40T prostate epithelial cells by __Chlamydia trachomatis__ in an in vitro infection assay. Furthermore, using truncated human SP‐D mutants, we demonstrate that SP‐D binds to __Chlamydia trachomatis__ via its carboxy‐terminal lectin domains. ## Conclusions Our in vitro studies suggest that SP‐D protects the prostate from infection by pathogens. SP‐D protein levels are increased at sites of inflammation in the prostate, suggesting SP‐D may also contrib

Who reads A role for surfactant protein D in innate immunity of the human prostate?

Author

Rebecca E. Oberley; Kelli L. Goss; Laila Dahmoush; Kevin A. Ault; Erika C. Crouch; Jeanne M. Snyder

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2005

Language

EN

Field

Medicine (Health Sciences)