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Harnessing immune response using reactive oxygen Species-Generating/Eliminating inorganic biomaterials for disease treatment 1 1 Introduction 2 2 ROS in the immune system 3 2.1 ROS in sensing danger signals 3 2.2 ROS in regulating immune cell function 4 2.3 ROS in immune suppression 4 2.4 Oxidative modification of ROS in immune response 5 3 ROS scavenging inorganic nanomaterials for disease treatment 5 3.1 Modulation of cytokines 5 3.1.1 Metal-based antioxidative nanomaterials 6 3.1.2 Ceria oxide nanoparticles 7 3.1.3 Manganese oxide-Based nanoparticles 8 3.1.4 Other ROS-Scavenging inorganic nanoparticles 8 3.2 Targeting immune cells 9 3.2.1 Polarization of macrophages 9 3.2.2 Inhibiting leukocytes recruitment 11 3.3 Normalizing NF-κB mediated signaling 12 3.4 Reversal of immunosuppressive TME 12 3.4.1 Inhibiting the activation of NF-κB signaling 12 4 ROS generating nanomaterials for disease treatment 12 4.1 Induction of immunogenic cell death (ICD) 12 4.1.1 Photodynamic therapy (PDT) 13 4.1.2 Radiotherapy (RT) 15 4.1.3 Chemical dynamic therapy (CDT) 15 4.2 Reprogramming Tumor-Associated Macrophages 16 4.3 Activation of inflammasomes 18 4.4 Recruitment of Macrophages 19 5 Conclusio

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nonfiction