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Risk Factors for the Deterioration of Pulmonary Function in Primary Ciliary Dyskinesia by Vanessa Fein; Christoph Maier; Anne Schlegtendal; Robin Denz; Cordula Koerner‐Rettberg; Folke Brinkmann is a Medicine article available to read on EtoBox.

What is Risk Factors for the Deterioration of Pulmonary Function in Primary Ciliary Dyskinesia about?

Background: PCD is a genetic disease leading to a decline in pulmonary function.There is only little knowledge of factors determining the long-term pulmonary outcome. Especially adherence has not been addressed yet although being an independent risk factor for an increased loss of lung capacity in other chronic respiratory diseases.Objective: Assessing the impact of bacterial airway colonization and adherence on long-term lung function in patients with PCD.Methods: Data on colonization and lung function parameters like forced expiratory volume in the first second (FEV 1, Z-score) and lung clearance index (LCI 2,5% ) were collected for 7.01 ± 2.2 years (893 quarters) in 44 PCD patients. Adherence was classified as good, moderate or poor. The impact of both adherence and colonization was assessed for the long-term course of FEV1, the association of colonization with lung function also quarterly.Statistics: Kruskall-Wallis test, T test, ANOVA, linear regression, linear mixed model.Results: Chronic colonization did not show any impact on the for long-term course of FEV 1 , but adherence was a significant factor: patients with good adherence showed better FEV 1 at the end of the observa

Who reads Risk Factors for the Deterioration of Pulmonary Function in Primary Ciliary Dyskinesia?

Author

Vanessa Fein; Christoph Maier; Anne Schlegtendal; Robin Denz; Cordula Koerner‐Rettberg; Folke Brinkmann

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)