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Antibiotic Prophylaxis in the Management of Open Fractures: A Systematic Survey of Current Practice and Recommendations by Yaping Chang; Mohit Bhandari; Kan Lun Zhu; Reza Donald Mirza; Melody Ren; Sean Alexander Kennedy; Ahmed Negm; Neera Bhatnagar; Faysal N. Naji; Lazar Milovanovic; Yutong Fei; Arnav Agarwal; Rakhshan Kamran; Sung Min Cho; Stefan Schandelmaier; Li Wang; Lin Jin; Shiyun Hu; Yanping Zhao; Luciane Cruz Lopes; Mei Wang; Brad Petrisor; Bill Ristevski; Reed A.C. Siemieniuk; Gordon H. Guyatt is a Medicine article available to read on EtoBox.

What is Antibiotic Prophylaxis in the Management of Open Fractures: A Systematic Survey of Current Practice and Recommendations about?

## Background: Evidence with regard to antibiotic prophylaxis for patients with open fractures of the extremities is limited. we therefore conducted a systematic survey addressing current practice and recommendations. ## Methods: We included publications from january 2007 to june 2017. we searched embase, medline, cinahl, the cochrane central registry of controlled trials (central), and the cochrane database of systematic reviews for clinical studies and surveys of surgeons; worldcat for textbooks; and web sites for guidelines and institutional protocols. ## Results: We identified 223 eligible publications that reported 100 clinical practice patterns and 276 recommendations with regard to systemic antibiotic administration, and 3 recommendations regarding local antibiotic administration alone. most publications of clinical practice patterns used regimens with both gram-positive and gram-negative coverage and continued the administration for 2 to 3 days. most publications recommended prophylactic systemic antibiotics. most recommendations suggested gram-positive coverage for less severe injuries and administration duration of 3 days or less. for more severe injuries, most recommenda

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Author

Yaping Chang; Mohit Bhandari; Kan Lun Zhu; Reza Donald Mirza; Melody Ren; Sean Alexander Kennedy; Ahmed Negm; Neera Bhatnagar; Faysal N. Naji; Lazar Milovanovic; Yutong Fei; Arnav Agarwal; Rakhshan Kamran; Sung Min Cho; Stefan Schandelmaier; Li Wang; Lin Jin; Shiyun Hu; Yanping Zhao; Luciane Cruz Lopes; Mei Wang; Brad Petrisor; Bill Ristevski; Reed A.C. Siemieniuk; Gordon H. Guyatt

Published

2019

Language

EN

Field

Medicine (Health Sciences)