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Can I read Inferring Chromatin Accessibility During Murine Hematopoiesis Through Phylogenetic Analysis on EtoBox?
Inferring Chromatin Accessibility During Murine Hematopoiesis Through Phylogenetic Analysis by Kanako O. Koyanagi is a Medicine article available to read on EtoBox.
What is Inferring Chromatin Accessibility During Murine Hematopoiesis Through Phylogenetic Analysis about?
## Objective Diversification of cell types and changes in epigenetic states during cell differentiation processes are important for understanding development. Recently, phylogenetic analysis using DNA methylation and histone modification information has been shown useful for inferring these processes. The purpose of this study was to examine whether chromatin accessibility data can help infer these processes in murine hematopoiesis. ## Results Chromatin accessibility data could partially infer the hematopoietic differentiation hierarchy. Furthermore, based on the ancestral state estimation of internal nodes, the open/closed chromatin states of differentiating progenitor cells could be predicted with a specificity of 0.86–0.99 and sensitivity of 0.29–0.72. These results suggest that the phylogenetic analysis of chromatin accessibility could offer important information on cell differentiation, particularly for organisms from which progenitor cells are difficult to obtain. ## Supplementary Information The online version contains supplementary material available at 10.1186/s13104-023-06507-8.
Who reads Inferring Chromatin Accessibility During Murine Hematopoiesis Through Phylogenetic Analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kanako O. Koyanagi
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)