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Erythropoietin improve spatial memory impairment following methamphetamine neurotoxicity by inhibition of apoptosis, oxidative stress and neuroinflammation in CA1 area of hippocampus by Behzad Garmabi; Reza Mohaddes; Fatemeh Rezvani; Fahimeh Mohseni; Hossein Khastar; Mehdi khaksari is a Neuroscience article available to read on EtoBox.
What is Erythropoietin improve spatial memory impairment following methamphetamine neurotoxicity by inhibition of apoptosis, oxidative stress and neuroinflammation in CA1 area of hippocampus about?
Objective Methamphetamine (METH) is one of the most widely used addictive drugs, and addiction to it is on the rise all over the world. METH abuse has long-term damaging effects that reduce memory and impair cognitive functions. According to studies, the observed effects are strongly related to the nerve cell damage caused by METH, which leads to neurotoxicity. Some of these intra-neuronal events include dopamine oxidation, excitotoxicity, and oxidative stress. Erythropoietin (EPO) is a hormone produced primarily by the kidneys and, in small quantities, by the liver. Studies have shown that EPO exhibits considerable neuroprotective effects. This study aimed to investigate the protective effects of EPO on METH neurotoxicity. Methods Initially, 48 male Wistar rats, weighing 250–300 g, were randomly assigned to four groups: control (n = 12), METH (n = 12), and METH+EPO (2500, 5000 IU/kg/IP- n = 12). METH was injected intraperitoneally at a dose of 40 mg per kg of body weight (four injections of 10 mg every two hours) to induce neurotoxicity. EPO was injected at doses of 2500 and 5000 IU/kg seven days after the last METH administration (ip). Morris water maze test was performed followi
Who reads Erythropoietin improve spatial memory impairment following methamphetamine neurotoxicity by inhibition of apoptosis, oxidative stress and neuroinflammation in CA1 area of hippocampus?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Behzad Garmabi; Reza Mohaddes; Fatemeh Rezvani; Fahimeh Mohseni; Hossein Khastar; Mehdi khaksari
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)