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New cerium(III) complexes of coumarins – Synthesis, characterization and cytotoxicity evaluation by Irena Kostova; Georgi Momekov is a Chemistry article available to read on EtoBox.
What is New cerium(III) complexes of coumarins – Synthesis, characterization and cytotoxicity evaluation about?
Complexes of cerium(III) with bis(4-hydroxy-2-oxo-2H-chromen-3-yl)-pyridin-2-yl-methane, bis(4-hydroxy-2-oxo-2H-chromen-3-yl)pyridin-3-yl-methane and bis(4-hydroxy-2-oxo-2H-chromen-3-yl)-pyridin-4-yl-methane were synthesized by reaction of cerium(III) salt and the ligands, in amounts equal to metaleligand molar ratio of 1:2. The cerium(III) complexes with bis-coumarins were characterized by different physicochemical methods e elemental analysis, IR-, Raman-, 1 H NMR-and 13 C NMR-spectroscopy and mass-spectral data. The spectral data of cerium(III) complexes were interpreted on the basis of comparison with the spectra of the free ligands. This analysis showed that in the Ce(III) complexes the ligands coordinated to the metal ion through both deprotonated hydroxyl groups. On the basis of the n(C]O) red shift observed, participation of the carbonyl groups in the coordination to the metal ion was also suggested. Cytotoxic screening by MTT assay was carried out. In the present study we performed comparative evaluation of the cytotoxic effects of the three newly synthesized cerium complexes against the acute myeloid leukemia derived HL-60 and the chronic myeloid leukemia (CML)-derived BV
Who reads New cerium(III) complexes of coumarins – Synthesis, characterization and cytotoxicity evaluation?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Irena Kostova; Georgi Momekov
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 2008
- Language
- EN
- Field
- Chemistry (Physical Sciences)