About this Medicine article
‘NC100150’, a preparation of iron oxide nanoparticles ideal for positive-contrast MR angiography by Kenneth E. Kellar; Dennis K. Fujii; Wolfgang H. H. Gunther; Karen Briley-Sæbø; Marga Spiller; Seymour H. Koenig is a Medicine article available to read on EtoBox.
A laboratory-scale synthesis of NC100150 (iron oxide particles with an oxidized starch coating) was characterized by magnetization measurements (vibrating sample magnetometry, VSM), relaxometry (1/T~ NMRD profiles and lIT 2 at 10 and 20 MHz), and dynamic light scattering (photon correlation spectroscopy, PCS). The results were related to give a self-consistent physical description of the particles: a water-impenetrable part making up 12% of the total particle volume, 82% of this volume consisting of an iron oxide core and the remaining 18% consisting of an oxidized starch rind; and, a water-penetrable part making up 88% of the total particle volume, consisting of oxidized starch polymers and entrained water molecules. Relating the magnetization to the relaxometry results required that the oxidized starch coating slows the diffusivity of solvent water molecules in the vicinity of the iron oxide cores. The effect of the organic coating on water diffusivity, not previously considered in the application of relaxation theory to iron oxide nanoparticles, is supported by the much greater (factor of about 2) diameter obtained from the dynamic light scattering measurements in comparison to
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- Author
- Kenneth E. Kellar; Dennis K. Fujii; Wolfgang H. H. Gunther; Karen Briley-Sæbø; Marga Spiller; Seymour H. Koenig
- Publisher
- Springer Science and Business Media LLC
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)