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Extensive clinical experience: Hypothalamic-pituitary-adrenal axis recovery after adrenalectomy for corticotropin-independent cortisol excess by Maria Daniela Hurtado; Tiffany Cortes; Neena Natt; William F. Young; Irina Bancos is a Medicine article available to read on EtoBox.

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## Objective: To identify predictors of hypothalamic-pituitary-adrenal (hpa) axis recovery interval and severity of glucocorticoid withdrawal symptoms (gws) in patients undergoing adrenalectomy for corticotropin-independent cortisol excess. ## Design: This is a retrospective study of patients with mild autonomous cortisol excess (mace), moderate and severe cushing syndrome (cs) who developed adrenal insufficiency after unilateral adrenalectomy between 1998 and 2017. ## Results: Adrenalectomy was performed in 81 patients (79% women, median age 52 years [iqr 42-62]). hpa axis recovery occurred at a median of 4.3 months (iqr 1.6-11.4) after adrenalectomy (severe cs vs moderate cs vs mace: median 11.4 vs 2.8 vs 2.1 months, p 10 μg/dl or >276 nmol/l (9.7 vs 1.3 months if cortisol ≤10 μg/dl or ≤276 nmol/l, p < 0.01); body mass index (for every 3 kg/m decrease, glucocorticoid taper increased by 1 month, p < 0.05); age <45 (11.4 vs 2.3 months if ≥45 years, p 1 year (11.4 vs 2.8 months if ≤1 year); moon facies (11.4 vs 2.2 months if no rounding of the face); and myopathy (13.1 vs 2.7 months if no myopathy, p < 0.05). patients with severe cs had a higher incidence of gws compared to patien

Who reads Extensive clinical experience: Hypothalamic-pituitary-adrenal axis recovery after adrenalectomy for corticotropin-independent cortisol excess?

Author

Maria Daniela Hurtado; Tiffany Cortes; Neena Natt; William F. Young; Irina Bancos

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

2018

Language

EN

Field

Medicine (Health Sciences)