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This study synthesized six thiazole-derived amide compounds to inhibit the PfPKG enzyme in Plasmodium falciparum, which causes malaria. NMR and IR spectroscopy were used to characterize the compounds. AutoDocking software predicted the binding affinities to PfPKG, with compound 6 having the highest predicted binding and compound 5 the lowest. In vitro, compound 4 showed the best percent inhibition around 30-39% at 10 μM. While inhibition was weak, this research provides a foundation for further drug discove

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api-700030358

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