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Immunohistochemical Detection of Lymph Node Micrometastases from Gallbladder Carcinoma Using Monoclonal Anticytokeratin Antibody by Naoyuki Yokoyama; Yoshio Shirai; Katsuyoshi Hatakeyama is a Medicine article available to read on EtoBox.

What is Immunohistochemical Detection of Lymph Node Micrometastases from Gallbladder Carcinoma Using Monoclonal Anticytokeratin Antibody about?

## BACKGROUND. The objective of this study was to define the sensitivity and clinical implications of the immunohistochemical detection of lymph node micrometastases in patients with gallbladder carcinoma (GBC). ## METHODS. The authors examined a total of 385 regional lymph nodes taken from 26 consecutive patients with GBC who had undergone a radical resection. Histologic sections of the primary tumor and regional lymph nodes in each case were stained with both hematoxylin and eosin and an antibody against cytokeratins 8 and 18 (CAM5.2). A "micrometastasis" was defined as a metastasis missed on routine histologic examination with hematoxylin and eosin but detected by immunohistochemical examination with CAM5.2. Survival rates were calculated only in patients with Stage II or more advanced stage disease. ## RESULTS. All primary tumors were positive for CAM5.2. Routine histologic examination revealed 53 positive lymph nodes that were stained consistently with CAM5.2. Another seven lymph nodes had micrometastases. Patients with micrometastases showed a significantly worse survival rate than those without micrometastases (P ϭ 0.037, log rank test). Among patients with no lymph node dis

Who reads Immunohistochemical Detection of Lymph Node Micrometastases from Gallbladder Carcinoma Using Monoclonal Anticytokeratin Antibody?

Author

Naoyuki Yokoyama; Yoshio Shirai; Katsuyoshi Hatakeyama

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1999

Language

EN

Field

Medicine (Health Sciences)