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Can I read Structure and Solid-state Chemistry of Anhydrous and Hydrated Crystal Forms of the Trimethoprim-sulfamethoxypyridazine 1:1 Molecular Complex on EtoBox?
Structure and Solid-state Chemistry of Anhydrous and Hydrated Crystal Forms of the Trimethoprim-sulfamethoxypyridazine 1:1 Molecular Complex by Giampiero Bettinetti; Mino R. Caira; Athos Callegari; Marcello Merli; Milena Sorrenti; Carla Tadini is a Chemistry article available to read on EtoBox.
What is Structure and Solid-state Chemistry of Anhydrous and Hydrated Crystal Forms of the Trimethoprim-sulfamethoxypyridazine 1:1 Molecular Complex about?
The crystal structure of the equimolar trimethoprim (TMP) and sulfamethoxypyridazine (SMPD) complex in the anhydrous form (TMP.SMPD) and that of the species with 1.5 molecules of water of crystallization (TMP.SMPD.W) are reported in this article. X-ray powder diffraction patterns (both computer generated and experimental) and thermal analytical data from differential scanning calorimetry (DSC) and thermogravimetry useful for the characterization of TMP.SMPD and TMP.SMPD.W are provided. The stability of TMP.SMPD.W, which retains its crystallographic order under 0% relative humidity (RH) conditions at room temperature (22°C) and 20 mmHg, is accounted for in terms of crystal structure and hydrogen bonding. Transformation of TMP.SMPD to the hydrate complex by exposure to ≈100% RH, suspension in water, and wet granulation, and dehydration of TMP.SMPD.W by thermal treatment and by desiccation with methanol were investigated and tentatively interpreted in terms of crystal properties. Interactions in the physical mixture of TMP and SMPD by grinding, compression, heating, and contact with water were also studied. Water-mediated formation of TMP.SMPD.W by wetting and metastable eutectic melt
Who reads Structure and Solid-state Chemistry of Anhydrous and Hydrated Crystal Forms of the Trimethoprim-sulfamethoxypyridazine 1:1 Molecular Complex?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Giampiero Bettinetti; Mino R. Caira; Athos Callegari; Marcello Merli; Milena Sorrenti; Carla Tadini
- Publisher
- John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)
- Published
- 2000
- Language
- EN
- Field
- Chemistry (Physical Sciences)