Can I read PLT‐associated immunoglobulin increases during PLT storage on EtoBox?

PLT‐associated immunoglobulin increases during PLT storage by Laura Cooling; Theodore A.W. Koerner is a Medicine article available to read on EtoBox.

What is PLT‐associated immunoglobulin increases during PLT storage about?

## CMV DNA in blood donors with IgM and IgG CMV antibodies Strategies for preventing posttransfusion CMV infections include testing for CMV antibodies, CMV DNA, and/or WBC reduction of blood components. 1,2 Early studies with molecular methods produced conflicting results. Nevertheless, recent investigations show that improved CMV PCR assays do not necessarily increase detection of CMV DNA in healthy CMV-seronegative blood donors. 3,4 We confirm these findings in a study of 244 plasma and WBC fractions and 176 serum samples from 420 donors in the Vienna, Austria, region (384 randomly selected and 36 samples selected for IgM anti-CMV reactivity). We tested for IgM and IgG CMV antibodies in serum or plasma with two ELISAs (Enzygnost anti-CMV IgM and Enzygnost anti-CMV IgG, Dade Behring, Marburg, Germany). Results were interpreted to be positive if the corrected absorbance values ( D A = [A antigen -A control antigen ] ¥ correction factor) were greater than the cutoff of 0.2 OD, negative if the absorbance values were less than the cutoff of 0.1 OD, and equivocal if the absorbance values were between 0.1 and 0.2 OD in the first test and in retesting. CMV PCR screening was performed on

Who reads PLT‐associated immunoglobulin increases during PLT storage?

Author

Laura Cooling; Theodore A.W. Koerner

Publisher

Elsevier Science; John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Elsevier; Elsevier BV; Wiley (ISSN 0372-1248)

Published

2003

Language

EN

Field

Medicine (Health Sciences)