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Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains by Andreas Tietze; Yan‐Ni Shi; Max Kronenwerth; Helge B. Bode is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains about?

## Abstract Nonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2‐electron reduction of the enzyme‐bound thioester releasing the generated peptides as C‐terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that originates from an aldehyde‐generating minimal NRPS termed ATRed in entomopathogenic Xenorhabdus indica. Reductase domains were also investigated in terms of NRPS engineering and, although no general applicable approach was deduced, we show that they can indeed be used for the production of similar natural and unnatural pyrazinones.

Who reads Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains?

Author

Andreas Tietze; Yan‐Ni Shi; Max Kronenwerth; Helge B. Bode

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1439-4227)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)