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Lymphopenia and Radiation Dose to Circulating Lymphocytes With Neoadjuvant Chemoradiation in Esophageal Squamous Cell Carcinoma by Tsz Him So; Sik Kwan Chan; Wing Lok Chan; Horace Choi; Chi Leung Chiang; Victor Lee; Tai Chung Lam; Ian Wong; Simon Law; Dora Kwong; Feng Ming (Spring) Kong; Jian Yue Jin; Ka On Lam is a Medicine article available to read on EtoBox.
What is Lymphopenia and Radiation Dose to Circulating Lymphocytes With Neoadjuvant Chemoradiation in Esophageal Squamous Cell Carcinoma about?
## Purpose We hypothesized that radiation-induced lymphopenia could be predicted by the effective dose to the circulating immune cells (EDIC) in advanced esophageal squamous cell carcinoma treated with trimodality therapy according to the Dutch ChemoRadiotherapy for Oesophageal cancer followed by Surgery Study (CROSS) trial regimen. To test this hypothesis, we examined the effect of EDIC on the degree of lymphocyte drop (lymphocyte nadir). ## Methods and Materials Patients with advanced nonmetastatic esophageal squamous cell carcinoma treated in a single tertiary cancer center from 2012 to 2018 were eligible for this study. All patients had to have a radiation therapy plan available for EDIC computation and received neoadjuvant chemoradiation according to the Dutch CROSS trial regimen before radical esophagectomy. The EDIC was calculated as a function of integral doses to the lung, heart, and total body with a verified mathematical model. The association between EDIC and lymphocyte nadir was studied, and the relationships of overall survival (OS) with lymphocyte nadir and EDIC were assessed using multivariable Cox regression model. ## Results This analysis included 92 eligible cons
Who reads Lymphopenia and Radiation Dose to Circulating Lymphocytes With Neoadjuvant Chemoradiation in Esophageal Squamous Cell Carcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Tsz Him So; Sik Kwan Chan; Wing Lok Chan; Horace Choi; Chi Leung Chiang; Victor Lee; Tai Chung Lam; Ian Wong; Simon Law; Dora Kwong; Feng Ming (Spring) Kong; Jian Yue Jin; Ka On Lam
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)