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Specific Effect of Levetiracetam in Experimental Human Pain Models\* by Thomas P. Enggaard; Niels A. Klitgaard; Søren H. Sindrup is a Medicine article available to read on EtoBox.

What is Specific Effect of Levetiracetam in Experimental Human Pain Models\* about?

## Abstract __Background__ Levetiracetam is a new antiepileptic drug. There is only limited experience with levetiracetam in clinical neuropathic pain. __Aim__ To test the analgesic effect of levetiracetam in a human experimental pain model in order to obtain preclinical evidence for its potential effect in neuropathic pain. __Methods__ Sixteen healthy volunteers completed a randomized, double‐blind, cross‐over trial with a single oral dose of 1500 mg levetiracetam against placebo. Pain tests included pain detection and tolerance to single electrical stimulation and temporal pain summation threshold to repetitive electrical stimulation (3 Hz) of the sural nerve. __Results__ Levetiracetam significantly increased the pain tolerance thresholds (__p__ = 0.04), and the pain detection thresholds tended to be increased (__p__ = 0.06), whereas levetiracetam had no effect on temporal pain summation thresholds (__p__ = 0.30). __Conclusion__ Levetiracetam has an analgesic effect in the electrical sural nerve stimulation pain model, but it did not increase temporal pain summation threshold. Levetiracetam may still be effective in clinical neuropathic pain.

Who reads Specific Effect of Levetiracetam in Experimental Human Pain Models\*?

Author

Thomas P. Enggaard; Niels A. Klitgaard; Søren H. Sindrup

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 1090-3801)

Published

2006

Language

EN

Field

Medicine (Health Sciences)