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Pre- and Postinduction Chemotherapy Target Volume Delineation in Head and Neck Cancer: Preliminary Results from an Expert Panel by D.I. Rosenthal; C.D. Fuller; K.K. Ang; D.M. Brizel; A. Eisbruch; Q.T. Le; N.Y. Lee; B. O'Sullivan; J. Duppen; C.R.N. Rasch is a Medicine article available to read on EtoBox.

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Materials/Methods: Fifteen patients with biopsy proven primary HNC undergoing primary RT with or without concurrent chemotherapy underwent CTP on an IRB approved protocol at baseline, Weeks 2, 4, 6 of RT and 6 weeks after RT. Perfusion imaging was performed in a 4 cm craniocaudal region of interest encompassing the tumor volume. CTP parameters including Blood Volume (BV), Blood Flow (BF), Mean Transit Time (MTT), and Capillary Permeability (CP) in the salivary gland were measured using a deconvolution-based analysis. Patients were assessed for xerostomia three months after completion of treatment. Results: Ten of 15 patients had serial CTP studies with measurable salivary gland data at baseline, at 2, 4, and 6 weeks during RT, and 6 weeks post-RT. Primary tumor sites treated included oropharynx (3), larynx (2), oral cavity (1) nasopharynx (2), hypopharynx (1) and auricle (1). At 3-month follow-up Grade 1 xerostomia was present in 8 of 15 patients in the study and in 6 of 10 patients with serial salivary CTP data. At baseline, the mean parotid gland blood flow (BF), blood volume (BV), mean transit time (MTT) and capillary permeability (CP) was 52.6 mL/100g/min (standard deviation, S

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Author

D.I. Rosenthal; C.D. Fuller; K.K. Ang; D.M. Brizel; A. Eisbruch; Q.T. Le; N.Y. Lee; B. O'Sullivan; J. Duppen; C.R.N. Rasch

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2009

Language

EN

Field

Medicine (Health Sciences)