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What is In-Silico Analysis of CCM2 Gene Variants about?

This study investigates nonsynonymous genomic variants in the CCM2 gene, focusing on the phosphotyrosine binding (PTB) domain and its dual cores. Using bioinformatic tools, the research confirms that pathogenic mutations primarily affect the local tertiary structure of the PTB core without impacting the neighboring core, supporting the existence of independently functional dual cores. The findings enhance understanding of the structural implications of genetic variants associated with cerebral cavernous mal

Author

Pritam

Language

EN