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Association between diabetes and thiamine status - A systematic review and meta-analysis by Dan Ziegler; Karlheinz Reiners; Alexander Strom; Rima Obeid is a Medicine article available to read on EtoBox.

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Background Thiamine (vitamin B1) is an essential cofactor in glucose metabolism, but it remains unclear whether thiamine status is lower in individuals with diabetes compared to individuals with normal glucose metabolism. Aims We conducted a systematic review and meta-analysis to study whether the circulating concentrations of various thiamine analytes differ between people with and those without diabetes. Methods PubMed and the Cochrane Central Register of Controlled Trials were searched according to the study protocol. The standardized mean difference (SMD) and 95 % confidence intervals (CI) of thiamine markers between individuals with and without diabetes were used as effect size (random effects model). Subgroup analysis considered albuminuria as an additional variable. Results Out of the 459 articles identified, 24 full-texts were eligible for the systematic review, 20 of which qualified for the data analysis and four were evaluated for coherence. Compared to controls, individuals with diabetes showed lower concentrations of thiamine (pooled estimate SMD [95 % CI]: −0.97 [−1.89, −0.06]), thiamine monophosphate (−1.16 [−1.82, −0.50]), and total thiamine compounds (−1.01 [−1.48,

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Author

Dan Ziegler; Karlheinz Reiners; Alexander Strom; Rima Obeid

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)