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The effects of the selective and non‐peptide CXCR2 receptor antagonist SB225002 on acute and long‐lasting models of nociception in mice by Marianne N. Manjavachi; Nara L.M. Quintão; Maria Martha Campos; Isa K. Deschamps; Rosendo A. Yunes; Ricardo J. Nunes; Paulo C. Leal; João B. Calixto is a Medicine article available to read on EtoBox.
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## Abstract This study evaluated the antinociceptive effects of the selective and non‐peptide CXCR2 antagonist SB225002 in mouse models of pain. As assessed in different tests of spontaneous nociception, intraperitoneal (i.p.) administration of SB225002 caused consistent and dose‐related reduction of acetic acid‐induced abdominal constrictions, whereas it did not significantly affect the nociception evoked by formalin, capsaicin, glutamate or phorbol ester acetate (PMA). Systemic treatment with SB225002 strikingly reduced the spontaneous nociception induced by 8‐bromo‐cAMP (8‐Br‐cAMP), or mechanical hypernociception induced by prostaglandin E~2~ (PGE~2~), epinephrine, or the keratinocyte‐derived chemokine (KC). In the carrageenan model, SB225002 markedly reduced mechanical hypernociception when administered by i.p., intrathecal (i.t.) or intracerebroventricular (i.c.v.) routes, or even when co‐administered with carrageenan into the mouse paw, indicating peripheral and central sites of action for SB225002. In addition, i.p. treatment with SB225002 significantly attenuated the increase in MPO activity or the elevation of IL‐1β, TNFα or KC levels following carrageenan injection. In th
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- Author
- Marianne N. Manjavachi; Nara L.M. Quintão; Maria Martha Campos; Isa K. Deschamps; Rosendo A. Yunes; Ricardo J. Nunes; Paulo C. Leal; João B. Calixto
- Publisher
- Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 1090-3801)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)