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Induction of Rapid, Activity-dependent Neuronal–glial Remodelling in the Adult Rat Hypothalamus in Vitro by Sarah L. Langle; Dominique A. Poulain; Dionysia T. Theodosis is a Neuroscience article available to read on EtoBox.

What is Induction of Rapid, Activity-dependent Neuronal–glial Remodelling in the Adult Rat Hypothalamus in Vitro about?

## Abstract The hypothalamic oxytocinergic system offers a remarkable model of morphological plasticity in the adult because its neurons and astrocytes undergo mutual remodelling in relation to differing physiological conditions. Among various factors involved in such plasticity, oxytocin (OT) itself appears of primary importance as its central administration resulted in morphological changes similar to those brought on by physiological stimuli. In the present study, we applied OT on acute hypothalamic slices from adult rats that included the supraoptic nucleus. Using ultrastructural morphometric analyses, we found that it induced a significant reduction of astrocytic coverage of OT neurons, leaving their surfaces directly juxtaposed, to an extent similar to that detected __in vivo__ under conditions like lactation. These neuronal–glial changes were rapid and reversible, occurring within a few hours, and specifically mediated via OT receptors. They were potentiated by oestrogen and depended on calcium mobilization and __de novo__ protein synthesis. Moreover, they depended on concurrent neuronal activation brought on by hyperosmotic stimulation or blockade of inhibitory GABAergic ne

Who reads Induction of Rapid, Activity-dependent Neuronal–glial Remodelling in the Adult Rat Hypothalamus in Vitro?

Author

Sarah L. Langle; Dominique A. Poulain; Dionysia T. Theodosis

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2003

Language

EN

Field

Neuroscience (Life Sciences)