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Helicobacter pylori effects on gastritis, gastrin and enterochromaffin-like cells in Zollinger–Ellison syndrome and non-Zollinger–Ellison syndrome acid hypersecretors treated long-term with lansoprazole by B. I. Hirschowitz; M. M. Haber is a Medicine article available to read on EtoBox.

What is Helicobacter pylori effects on gastritis, gastrin and enterochromaffin-like cells in Zollinger–Ellison syndrome and non-Zollinger–Ellison syndrome acid hypersecretors treated long-term with lansoprazole about?

## Background: __Helicobacter pylori__ is said to cause atrophy of the gastric corpus and enterochromaffin‐like cell proliferation in gastro‐oesophageal reflux disease (GERD) patients treated long‐term with a proton pump inhibitor. ## Aims: To determine the effect of __H. pylori__ infection on gastritis, enterochromaffin‐like cell density and hyperplasia, mucosal atrophy and serum gastrin in patients with gastric hypersecretion (basal acid output gt; 15 mmol/h) with either hypergastrinemia (Zollinger–Ellison syndrome) or normal gastrin (non‐Zollinger–Ellison syndrome) before and during long‐term treatment with lansoprazole. ## Methods: Lansoprazole was individually titrated to reduce basal acid output to < 5 mmol/h (< 1 mmol/h in post‐surgical Zollinger–Ellison syndrome). Gastric corpus biopsies were obtained every 6 months before treatment and up to 8 years later. ## Results: __H. pylori__ was present in corpus biopsies in ≈ 50%, causing active gastritis which resolved rapidly in 15 subjects after elimination of __H. pylori__. Patchy mild/moderate corpus atrophy was present at entry in two and at the end in four out of 60 patients, one being __H. pylori__‐positive. Intestinal meta

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Author

B. I. Hirschowitz; M. M. Haber

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

2001

Language

EN

Field

Medicine (Health Sciences)