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Progressive Glomerular Toxicity of Ifosfamide in Children by Prasad, Vinod K.; Lewis, Ian J.; Aparicio, Samuel R.; Heney, David; Hale, Juliet P.; Bailey, Clifford C.; Kinsey, Sally E. is a Medicine article available to read on EtoBox.

What is Progressive Glomerular Toxicity of Ifosfamide in Children about?

Glomerular toxicity following ifosfamide (IFO) is not as well recognized as renal tubular damage. Following a case of ifosfamide-induced renal failure with histological evidence of glomerular changes, we undertook a retrospective study of all IFO-treated children to assess the extent and severity of its glomerular toxicity and to identify possible predisposing factors. Thirtyseven children with a follow-up of 6 months or more from the end of chemotherapy were studied. They were a median of 10.8 years old (range 3.25-1 8.5), had received a median of 54 g/m2 (range 9-135) of IFO, and had a median follow-up of 29 months (range 6-68). The criteria to identify glomerular dysfunction were raised plasma creatinine (Per) values on two occasions or a low glomerular filtration rate (GFR) measured by Tc-99-DTPA clearance. Detailed assessment was carried out to identify other nephrotoxic influences in these children. Subjects in whom glomerular dysfunction could be causally linked to IF0 were compared with the rest of the group for a variety of predisposing factors. Of eight children with glomerular dysfunction, two had other nephrotoxic influences and were excluded from further analysis. In s

Who reads Progressive Glomerular Toxicity of Ifosfamide in Children?

Author

Prasad, Vinod K.; Lewis, Ian J.; Aparicio, Samuel R.; Heney, David; Hale, Juliet P.; Bailey, Clifford C.; Kinsey, Sally E.

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0098-1532)

Published

1996

Language

EN

Field

Medicine (Health Sciences)