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Emerging Insights into Mu Opioid Pharmacology by Gavril W. Pasternak; Steven R. Childers; Ying-Xian Pan is a Medicine article available to read on EtoBox.

What is Emerging Insights into Mu Opioid Pharmacology about?

Opioid analgesics, most of which act through mu opioid receptors, have long represented valuable therapeutic agents to treat severe pain. Concerted drug development efforts for over a 100 years have resulted in a large variety of opioid analgesics used in the clinic, but all of them continue to exhibit the side effects, especially respiratory depression, that have long plagued the use of morphine. The recent explosion in fatalities resulting from overdose of prescription and synthetic opioids has dramatically increased the need for safer analgesics, but recent developments in mu receptor research have provided new strategies to develop such drugs. This chapter reviews recent advances in developing novel opioid analgesics from an understanding of mu receptor structure and function. This includes a summary of the mechanism of agonist binding deduced from the crystal structure of mu receptors. It will also highlight the development of novel agonist mechanisms, including biased agonists, bivalent ligands, and allosteric modulators of mu receptor function, and describe how receptor phosphorylation modulates these pathways. Finally, it will summarize research on the alternative pre-mRNA

Who reads Emerging Insights into Mu Opioid Pharmacology?

Author

Gavril W. Pasternak; Steven R. Childers; Ying-Xian Pan

Publisher

Springer International Publishing : Imprint: Springer

Published

2019

Language

EN

ISBN

9783030336790

Field

Medicine (Life Sciences)