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Identification of miRNA biomarkers for stomach adenocarcinoma by Qian, Hao (author);Cui, Nanxue (author);Zhou, Qiao (author);Zhang, Shihai (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Identification of miRNA biomarkers for stomach adenocarcinoma about?

## Background Stomach adenocarcinoma (STAD) is a common malignant tumor in the world and its prognosis is poor, miRNA plays a role mainly by influencing the expression of mRNAs, and participates in the occurrence and development of tumors. However, reliable miRNA prognostic models for stomach adenocarcinoma remain to be identified. ## Results Using the data from the Cancer Genome Atlas (TCGA), a prognostic model of stomach adenocarcinoma was established including tumor stage and expression levels of 4 miRNAs (hsa-miR-379-3p, hsa-miR-2681-3p, hsa-miR-6499-5p and hsa-miR-6807-3p). A total of 50 ultimate target genes of these miRNAs were obtained through prediction. Enrichment analysis revealed that target genes were mainly concentrated in neural function and TGF-β and FoxO signaling pathways. Survival analysis showed that three model miRNAs (hsa-miR-379-3p, hsa-miR-2681-3p and hsa-miR-6807-3p) and five final target genes (__DLC1__, __LRFN5__, __NOVA1__, __POU3F2__ and __PRICKLE2__) were associated with the patient's overall survival outcome. ## Conclusions We used bioinformatics methods to screen new prognostic miRNA markers from TCGA and established a prognostic model of STAD, so as

Who reads Identification of miRNA biomarkers for stomach adenocarcinoma?

Author

Qian, Hao (author);Cui, Nanxue (author);Zhou, Qiao (author);Zhang, Shihai (author)

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)