About this Medicine article
Basaloid-squamous carcinoma of the nasopharynx. An epstein–barr virus–associated neoplasm compared with morphologically identical tumors occurring in other sites by Suk-King Wan; John K. C. Chan; Wai-Hon Lau; Timothy T. C. Yip is a Medicine article available to read on EtoBox.
Background. Basaloid-squamous carcinoma is a newly characterized, highly aggressive neoplasm occurring mostly in the base of tongue, hypopharynx, larynx, and esophagus. Its occurrence in the nasopharynx is rare. Methods. The clinicopathologic features of three cases of basaloid-squamous carcinoma of the nasopharynx are described and were studied for the presence of Epstein-Barr virus (EBV) by in situ hybridization for EBV-encoded small nuclear RNA (EBER). For comparison, basaloid-squamous carcinomas occurring in other sites also were studied for the presence of EBV. Results. EBER was detected in all 3 cases of basaloidsquamous carcinoma occurring in the nasopharynx, but in none of the 13 cases from other sites including the esophagus, larynx, pharynx, hypopharynx, and nasal cavity. The nasopharyngeal basaloid-squamous carcinomas occurred in two male and one female patients with an age range of 48-70 years. The serum immunoglobulin A against the EBV-viral capsid antigen was elevated in all three cases. Two patients developed cervical lymph node involvement during the course of the disease. All three patients were treated by radiotherapy and survived for longer than 34 months compare
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- Author
- Suk-King Wan; John K. C. Chan; Wai-Hon Lau; Timothy T. C. Yip
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 1995
- Language
- EN
- ISBN
- 9782820761002
- Field
- Medicine (Health Sciences)