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Ivabradine in Patients with ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock: A Preliminary Randomized Prospective Study by Francesco Barillà; Giuseppe Pannarale; Concetta Torromeo; Vincenzo Paravati; Maria Cristina Acconcia; Gaetano Tanzilli; Enrico Mangieri; Tania Dominici; Francesco Martino; Gaetano Pannitteri; Carlo Gaudio is a Medicine article available to read on EtoBox.

What is Ivabradine in Patients with ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock: A Preliminary Randomized Prospective Study about?

Background and objective An elevated heart rate (HR) is an independent risk factor for mortality and morbidity in patients with acute heart failure (HF). The purpose of this study was to evaluate the impact of ivabradine, a selective HR-lowering agent, in patients with cardiogenic shock (CS) complicating ST-elevation acute myocardial infarction (AMI). Methods Patients with post-AMI CS were randomized to standard treatment (SDT, 28 patients) or to standard treatment plus ivabradine (I ? SDT, 30 patients). In the presence of orotracheal intubation (OTI), ivabradine was administered by nasogastric intubation. HR, BP, New York Heart Association (NYHA) class, NT-proBNP, left ventricular ejection fraction (LVEF) and diastolic function (LVDF) were monitored at specific times after the onset of AMI. The primary (surrogate) end-point was the in-hospital halving of plasma NT-proBNP levels. The secondary end-points were cardiovascular death, hospital re-admission for worsening HF, and clinical and haemodynamic improvement. Results Treatment groups were statistically similar with regard to age, gender distribution, cardiovascular risk factors, number of diseased vessels and overall treated les

Who reads Ivabradine in Patients with ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock: A Preliminary Randomized Prospective Study?

Author

Francesco Barillà; Giuseppe Pannarale; Concetta Torromeo; Vincenzo Paravati; Maria Cristina Acconcia; Gaetano Tanzilli; Enrico Mangieri; Tania Dominici; Francesco Martino; Gaetano Pannitteri; Carlo Gaudio

Publisher

Springer Science and Business Media LLC

Published

2016

Language

EN

Field

Medicine (Health Sciences)