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Trophic Regulation of the Basal Ganglia : Focus on Dopamine Neurons by K. Fuxe, L. F. Agnati and B. Bjelke (Eds.) is a nonfiction available to read on EtoBox.

What is Trophic Regulation of the Basal Ganglia : Focus on Dopamine Neurons about?

Since 1940 brain and pituitary extracts have been known to be capable of stimulating the proliferation of cultured fibroblasts. In 1974, one of these substances was partially purified and named FGF; later it was realised there exists a family of fibroblast growth factors, of which the best characterised are the FGF-I and FGF-2 (aFGF, BFGF). More recent work has shown that FGFs have many actions and that they are active not only on fibroblasts, but also on a wide range of cell types including those of the central nervous system. This volume represents the state-of-the-art of our understanding of aFGF and bFGF in the basal ganglia. Thus, the localization of those growth factors, the control mechanisms of their expression, and their trophic actions are analyzed in relation to nerve cell survival as well as to the neurodegenerative diseases affecting, the basal ganglia. Some of the most advanced research on degenerative and regenerative features of the basal ganglia is also presented. These studies involve the actions of neurotrophins, epidermal growth factors, gangliosides and neuropeptides as well as their localization and expression in the basal ganglia. These discoveries should hel

Who reads Trophic Regulation of the Basal Ganglia : Focus on Dopamine Neurons?

Author

K. Fuxe, L. F. Agnati and B. Bjelke (Eds.)

Publisher

Elsevier Science Pub Co

Published

1994

Language

EN

ISBN

9781483103099

Category

nonfiction

Subjects

Medical, Science, Medicine