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Can I read Stimulation of the subthalamic nucleus and impulsivity: Release your horses on EtoBox?
Stimulation of the subthalamic nucleus and impulsivity: Release your horses by Benedicte Ballanger; Thilo van Eimeren; Elena Moro; Andres M. Lozano; Clement Hamani; Philippe Boulinguez; Giovanna Pellecchia; Sylvain Houle; Yu Yan Poon; Anthony E. Lang; Antonio P. Strafella is a Medicine article available to read on EtoBox.
What is Stimulation of the subthalamic nucleus and impulsivity: Release your horses about?
Objective: In Parkinson disease (PD) patients, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may contribute to certain impulsive behavior during high-conflict decisions. A neurocomputational model of the basal ganglia has recently been proposed that suggests this behavioral aspect may be related to the role played by the STN in relaying a "hold your horses" signal intended to allow more time to settle on the best option. The aim of the present study was 2-fold: 1) to extend these observations by providing evidence that the STN may influence and prevent the execution of any response even during low-conflict decisions; and 2) to identify the neural correlates of this effect. Methods: We measured regional cerebral blood flow during a Go/NoGo and a control (Go) task to study the motor improvement and response inhibition deficits associated with STN-DBS in patients with PD. Results: Although it improved Unified Parkinson Disease Rating Scale motor ratings and induced a global decrease in reaction time during task performance, STN-DBS impaired response inhibition, as revealed by an increase in commission errors in NoGo trials. These behavioral effects were accompanied by
Who reads Stimulation of the subthalamic nucleus and impulsivity: Release your horses?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Benedicte Ballanger; Thilo van Eimeren; Elena Moro; Andres M. Lozano; Clement Hamani; Philippe Boulinguez; Giovanna Pellecchia; Sylvain Houle; Yu Yan Poon; Anthony E. Lang; Antonio P. Strafella
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0364-5134)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)