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Can I read Bioactive Glycans in a Microbiome-directed Food for Children with Malnutrition on EtoBox?
Bioactive Glycans in a Microbiome-directed Food for Children with Malnutrition by Matthew C. Hibberd; Daniel M. Webber; Dmitry A. Rodionov; Suzanne Henrissat; Robert Y. Chen; Cyrus Zhou; Hannah M. Lynn; Yi Wang; Hao-Wei Chang; Evan M. Lee; Janaki Lelwala-Guruge; Marat D. Kazanov; Aleksandr A. Arzamasov; Semen A. Leyn; Vincent Lombard; Nicolas Terrapon; Bernard Henrissat; Juan J. Castillo; Garret Couture; Nikita P. Bacalzo; Ye Chen; Carlito B. Lebrilla; Ishita Mostafa; Subhasish Das; Mustafa Mahfuz; Michael J. Barratt; Andrei L. Osterman; Tahmeed Ahmed; Jeffrey I. Gordon is a Physics and Astronomy article available to read on EtoBox.
What is Bioactive Glycans in a Microbiome-directed Food for Children with Malnutrition about?
Evidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition^1–4^. Here we analyse biospecimens from a randomized, controlled trial of a microbiome-directed complementary food (MDCF-2) that produced superior rates of weight gain compared with a calorically more dense conventional ready-to-use supplementary food in 12–18-month-old Bangladeshi children with moderate acute malnutrition^4^. We reconstructed 1,000 bacterial genomes (metagenome-assembled genomes (MAGs)) from the faecal microbiomes of trial participants, identified 75 MAGs of which the abundances were positively associated with ponderal growth (change in weight-for-length __Z__ score (WLZ)), characterized changes in MAG gene expression as a function of treatment type and WLZ response, and quantified carbohydrate structures in MDCF-2 and faeces. The results reveal that two __Prevotella copri__ MAGs that are positively associated with WLZ are the principal contributors to MDCF-2-induced expression of metabolic pathways involved in utilizing the component glycans of MDCF-2. The predicted specificities of carbohydrate-active enzymes expressed by their polysaccharide
Who reads Bioactive Glycans in a Microbiome-directed Food for Children with Malnutrition?
It is typically read by researchers, students, and practitioners in Physics and Astronomy.
- Author
- Matthew C. Hibberd; Daniel M. Webber; Dmitry A. Rodionov; Suzanne Henrissat; Robert Y. Chen; Cyrus Zhou; Hannah M. Lynn; Yi Wang; Hao-Wei Chang; Evan M. Lee; Janaki Lelwala-Guruge; Marat D. Kazanov; Aleksandr A. Arzamasov; Semen A. Leyn; Vincent Lombard; Nicolas Terrapon; Bernard Henrissat; Juan J. Castillo; Garret Couture; Nikita P. Bacalzo; Ye Chen; Carlito B. Lebrilla; Ishita Mostafa; Subhasish Das; Mustafa Mahfuz; Michael J. Barratt; Andrei L. Osterman; Tahmeed Ahmed; Jeffrey I. Gordon
- Publisher
- Nature Publishing Group UK
- Published
- 2023
- Language
- EN
- Field
- Physics and Astronomy (Physical Sciences)