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Toll-Like Receptor-Dependent Activation of Antigen Presenting Cells by Hsp60, gp96 and Hsp70 by Henderson, Brian; Pockley, A. Graham is a scholarly article available to read on EtoBox.

What is Toll-Like Receptor-Dependent Activation of Antigen Presenting Cells by Hsp60, gp96 and Hsp70 about?

This book reviews current understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first-and-foremost protein-folding molecules. The current paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described

Author

Henderson, Brian; Pockley, A. Graham

Publisher

Cambridge University Press (Virtual Publishing)

Published

2005

Language

EN

ISBN

9780511546310