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Allogeneic Umbilical Cord Blood–Derived Mesenchymal Stem Cell Implantation Versus Microfracture for Large, Full-Thickness Cartilage Defects in Older Patients: A Multicenter Randomized Clinical Trial and Extended 5-Year Clinical Follow-up by Lim, Hong-Chul (author);Park, Yong-Beom (author);Ha, Chul-Won (author);Cole, Brian J. (author);Lee, Beom-Koo (author);Jeong, Hwa-Jae (author);Kim, Myung-Ku (author);Bin, Seong-Il (author);Choi, Chong-Hyuk (author);Choi, Choong Hyeok (author);Yoo, Jae-Doo (author);, for the Cartistem Research Group (author);Yoon, Jung-Ro (author);Chung, Jun-Young (author) is a Medicine article available to read on EtoBox.

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## Background: There is currently no optimal method for cartilage restoration in large, full-thickness cartilage defects in older patients. ## Purpose: To determine whether implantation of a composite of allogeneic umbilical cord blood–derived mesenchymal stem cells and 4% hyaluronate (UCB-MSC-HA) will result in reliable cartilage restoration in patients with large, full-thickness cartilage defects and whether any clinical improvements can be maintained up to 5 years postoperatively. ## Study Design: Randomized controlled trial; Level of evidence, 1. ## Methods: A randomized controlled phase 3 clinical trial was conducted for 48 weeks, and the participants then underwent extended 5-year observational follow-up. Enrolled were patients with large, full-thickness cartilage defects (International Cartilage Repair Society [ICRS] grade 4) in a single compartment of the knee joint, as confirmed by arthroscopy. The defect was treated either with UCB-MSC-HA implantation through mini-arthrotomy or with microfracture. The primary outcome was proportion of participants who improved by ≥1 grade on the ICRS Macroscopic Cartilage Repair Assessment (blinded evaluation) at 48-week arthroscopy. Seco

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Author

Lim, Hong-Chul (author);Park, Yong-Beom (author);Ha, Chul-Won (author);Cole, Brian J. (author);Lee, Beom-Koo (author);Jeong, Hwa-Jae (author);Kim, Myung-Ku (author);Bin, Seong-Il (author);Choi, Chong-Hyuk (author);Choi, Choong Hyeok (author);Yoo, Jae-Doo (author);, for the Cartistem Research Group (author);Yoon, Jung-Ro (author);Chung, Jun-Young (author)

Publisher

SAGE Publications

Published

2021

Language

EN

Field

Medicine (Health Sciences)