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Hippocampal and Cerebellar Changes in Acute Restraint Stress and the Impact of Pretreatment with Ceftriaxone by Amin, Shaimaa N.; Hassan, Sherif S.; Khashaba, Ahmed S.; Youakim, Magdy F.; Latif, Noha S. Abdel; Rashed, Laila A.; Yassa, Hanan D. is a Neuroscience article available to read on EtoBox.
What is Hippocampal and Cerebellar Changes in Acute Restraint Stress and the Impact of Pretreatment with Ceftriaxone about?
Acute restraint stress (ARS) is an unavoidable stress situation and may be encountered in different clinical situations. The aim of the current study was to investigate the effects of ARS on the hippocampus and cerebellum, assess the impact of these effects on the behavior and cognitive function, and determine whether pretreatment with ceftriaxone would attenuate the damages produced by ARS on the hippocampus and cerebellum. Four groups of male mice were included in this study: The control group, ARS group, ceftriaxone group, and ARS + ceftriaxone group. Tail suspension test, Y-maze task, and open field tests were used to assess depression, working spatial memory, and anxiety. The biochemical analyses included measurements of serum cortisol, tumor necrotic factor (TNF), interleukin-6, hippocampal expression of bone morphogenetic protein 9 (BMP9), lysosomal-associated membrane protein 1 (LAMP1), glutamate transporter 1 (GLT1), heat shock protein 90, cerebellar expression of S100 protein, glutamic acid decarboxylase (GAD), and carbon anhydrase. Histopathological examination of the brain sections was conducted on the hippocampus and cerebellum by hematoxylin and eosin stains in additi
Who reads Hippocampal and Cerebellar Changes in Acute Restraint Stress and the Impact of Pretreatment with Ceftriaxone?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Amin, Shaimaa N.; Hassan, Sherif S.; Khashaba, Ahmed S.; Youakim, Magdy F.; Latif, Noha S. Abdel; Rashed, Laila A.; Yassa, Hanan D.
- Publisher
- MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI AG, 2011- (ISSN 2076-3425)
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)