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Ab1063 Case Series Of Patients With Chronic Non-tuberculosis Mycobacteria Accompanying With Anti-interferon Gamma Antibody by Y. P. Tsao is a Medicine article available to read on EtoBox.

What is Ab1063 Case Series Of Patients With Chronic Non-tuberculosis Mycobacteria Accompanying With Anti-interferon Gamma Antibody about?

## Background: Anti-interferon (IFN) gamma antibody was a rare autoantibody which mainly been reported in Asia. It interferes the interferon pathway and eradication of intracellular pathogens, such as Salmonella or Mycobacteria. This rare disease should be raised for more awareness. ## Objectives: To analyze clinical presentations of the patients with anti-interferon (IFN) gamma antibody. ## Methods: We checked anti-IFN gamma antibody when patient fulfilled multiple NTM infection (especially bone marrow and lymph nodes). There are 6 cases of non-tuberculosis mycobacteria (NTM) infection accompanying with anti-IFN gamma antibody in our hospital from 2015 to 2019 of hospitalist ward, and the antibody titer is recorded. ## Results: Among these cases, patients had initial presentations of fever (100%), elevated CRP and ESR (100%), lymphadenopathy (67%), body weight loss (50%), and elevated LDH (50%). All the 6 cases had negative results of TB-PCR test, but 1 had positive result of interferon gamma release assay (IGRA, 17%). NTM was identified from lymph node biopsy (50%), sputum (33%), skin (33%), and bone marrow (33%). Different NTM was identified, including Mycobacterium abscessus, M

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Author

Y. P. Tsao

Publisher

BMJ

Published

2020

Language

EN

Field

Medicine (Health Sciences)