Can I read Changes of Cardiac Calcium Homeostasis in Spontaneously Hypertensive Rats on EtoBox?

Changes of Cardiac Calcium Homeostasis in Spontaneously Hypertensive Rats by A. M. Manso; A. Encabo; M. Ferrer; G. Balfagón; M. Salaices; J. Marín is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Changes of Cardiac Calcium Homeostasis in Spontaneously Hypertensive Rats about?

1 The aim of the present study was to assess the alterations in cardiac Ca^2+^ homeostasis induced by hypertension using electrically paced right ventricular strips from Wistar‐Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2 Basal contractile force was higher in SHR than in WKY. Similarly, the β‐adrenoceptor agonist isoprenaline (10 n m–10 μm) induced a concentration‐dependent positive inotropic effect that was higher in SHR than in WKY, which was in turn inhibited by the β‐adrenoceptor antagonist propranolol (1 μm) in both strains. 3 Preincubation of strips with the L‐type Ca^2+^ channel blockers, nifedipine (1 μm) or verapamil (10 μm), markedly inhibited the isoprenaline response, the inhibition being higher in SHR than in WKY. However, this inhibition was minor by the T‐type Ca^2+^ channel blocker mibefradil (10 μm). 4 Bay K 8644 (10 n m–10 μm), a L‐type Ca^2+^ channel activator induced a concentration‐dependent positive inotropic effect, that was greater in SHR than WKY. 5 Nifedipine and verapamil (both 0.1 n m–10 μm) inhibited in a concentration‐dependent way the inotropic effect induced by 0.3 μm isoprenaline or 1 μm Bay K 8644. The inhibition was higher in SHR than

Who reads Changes of Cardiac Calcium Homeostasis in Spontaneously Hypertensive Rats?

Author

A. M. Manso; A. Encabo; M. Ferrer; G. Balfagón; M. Salaices; J. Marín

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0144-1795)

Published

1999

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)