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Unveiling the therapeutic promise of natural products in alleviating drug‐induced liver injury: Present advancements and future prospects by Deepti Singh; Mohammad Afsar Khan; Hifzur R. Siddique is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Drug‐induced liver injury (DILI) refers to adverse reactions to small chemical compounds, biological agents, and medical products. These reactions can manifest as acute or chronic damage to the liver. From 1997 to 2016, eight drugs, including troglitazone, nefazodone, and lumiracoxib, were removed from the market due to their liver‐damaging effects, which can cause diseases. We aimed to review the recent research on natural products and their bioactive components as hepatoprotective agents in mitigating DILI. Recent articles were fetched via searching the PubMed, PMC, Google Scholar, and Web of Science electronic databases from 2010 to January 2023 using relevant keywords such as “natural products,” “acetaminophen,” “antibiotics,” “paracetamol,” “DILI,” “hepatoprotective,” “drug‐induced liver injury,” “liver failure,” and “mitigation.” The studies reveal that the antituberculosis drug (acetaminophen) is the most frequent cause of DILI, and natural products have been largely explored in alleviating acetaminophen‐induced liver injury. They exert significant hepatoprotective effects by preventing mitochondrial dysfunction and inflammation, inhibiting oxidative/nitrative st

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Author

Deepti Singh; Mohammad Afsar Khan; Hifzur R. Siddique

Publisher

Wiley

Published

2023

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)