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Constrained Photophysics of 5,7-dimethoxy-2,3,4,9-tetrahydro-1H-carbazol-1-one in the Bioenvironment of Serum Albumins: A Spectroscopic Endeavour Supported by Molecular Docking Analysis by Amrit Krishna Mitra; Abhishek Sau; Uttam Pal; Chandan Saha; Samita Basu is a Materials Science article available to read on EtoBox.

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This paper vividly indicates that steady state as well as time-resolved fluorescence techniques can serve as highly sensitive monitors to explore the interactions of 5,7-dimethoxy-2,3,4,9-tetrahydro-1H-carbazol-1-one with model transport proteins, bovine serum albumin (BSA) and human serum albumin (HSA). Besides these, we have used fluorescence anisotropy study to assess the degree of restrictions imparted by the micro-environments of serum albumins. Again, to speculate the triplet excited state interaction between such fluorophore and albumin proteins (BSA& HSA), laser flash-photolysis experiments have been carried out. Molecular docking experiments have also been performed to support the conclusions obtained from steady state experiments.

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Author

Amrit Krishna Mitra; Abhishek Sau; Uttam Pal; Chandan Saha; Samita Basu

Publisher

Springer Science and Business Media LLC

Published

2017

Language

EN

Field

Materials Science (Physical Sciences)