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Potent P2Y6 receptor mediated contractions in human cerebral arteries by Malin Malmsjö; Mingyan Hou; William Pendergast; David Erlinge; Lars Edvinsson is a Medicine article available to read on EtoBox.

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## Background: Extracellular nucleotides play an important role in the regulation of vascular tone and may be involved in cerebral vasospasm after subarachnoidal haemorrhage. this study was designed to characterise the contractile p2 receptors in endothelium-denuded human cerebral and omental arteries. the isometric tension of isolated vessel segments was recorded in vitro. p2 receptor mrna expression was examined by rt-pcr. ## Results: In human cerebral arteries, the selective p2y6 receptor agonist, udpbetas was the most potent of all the agonists tested (pec50 = 6.8 plusminus; 0.7). the agonist potency; udpbetas > alphabeta-meatp > utpgammas > atpgammas > adpbetas = 0, indicated the presence of contractile p2x1 p2y2, p2y4 and p2y6, but not p2y1 receptors, in human cerebral arteries. in human omental arteries, udpbetas was inactive. the agonist potency; alphabeta-meatp > atpgammas = utpgammas > adpbetas = udpbetas = 0, indicated the presence of contractile p2x1, and p2y2 receptors, but not p2y1 or p2y6 receptors, in human omental arteries. rt-pcr analysis of endothelium-denuded human cerebral and omental arteries demonstrated p2x1, p2y1, p2y2 and p2y6 receptor mrna expression. the

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Author

Malin Malmsjö; Mingyan Hou; William Pendergast; David Erlinge; Lars Edvinsson

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-2012.; Springer Science and Business Media LLC (ISSN 1471-2210)

Published

2003

Language

EN

Field

Medicine (Life Sciences)