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Does Exercise Attenuate Disease Progression in People With Parkinson’s Disease? A Systematic Review With Meta-Analyses by Jiecheng A Li; Marte B. Loevaas; Catherine Guan; Lina Goh; Natalie E. Allen; Margaret K. Y. Mak; Jinglei Lv; Serene S. Paul is a Medicine article available to read on EtoBox.
What is Does Exercise Attenuate Disease Progression in People With Parkinson’s Disease? A Systematic Review With Meta-Analyses about?
## Introduction Exercise has many benefits for people with Parkinson’s disease (PD) and has been suggested to modify PD progression, but robust evidence supporting this is lacking. ## Objective This systematic review (PROSPERO registration: CRD42020169999) investigated whether exercise may have neuroplastic effects indicative of attenuating PD progression. ## Methods Six databases were searched for randomized controlled trials (RCTs) that compared the effect of exercise to control (no or sham exercise) or to another form of exercise, on indicators of PD progression (eg, brain-derived neurotrophic factor [BDNF], brain activation, “off” Unified Parkinson’s Disease Rating Scale [UPDRS] scores). Trial quality was assessed using the Physiotherapy Evidence Database Scale. Random-effects meta-analyses were performed where at least 3 comparable trials reported the same outcome; remaining results were synthesized narratively. ## Results Forty-nine exercise trials involving 2104 PD participants were included. Compared to control, exercise improved “off” UPDRS motor scores (Hedge’s g −0.39, 95% CI: −0.65 to −0.13, __P__ = .003) and BDNF concentration (Hedge’s g 0.54, 95% CI: 0.10-0.98, __P__
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- Author
- Jiecheng A Li; Marte B. Loevaas; Catherine Guan; Lina Goh; Natalie E. Allen; Margaret K. Y. Mak; Jinglei Lv; Serene S. Paul
- Publisher
- SAGE Publications
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)