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Can I read Electroselective and Controlled Reduction of Cyclic Imides to Hydroxylactams and Lactams on EtoBox?
Electroselective and Controlled Reduction of Cyclic Imides to Hydroxylactams and Lactams by Ya Bai; Lingling Shi; Lianyou Zheng; Shulin Ning; Xin Che; Zhuoqi Zhang; Jinbao Xiang is a Chemistry article available to read on EtoBox.
What is Electroselective and Controlled Reduction of Cyclic Imides to Hydroxylactams and Lactams about?
An efficient and practical electrochemical method for selective reduction of cyclic imides has been developed using a simple undivided cell with carbon electrodes at room temperature. The reaction provides a useful strategy for the rapid synthesis of hydroxylactams and lactams in a controllable manner, which is tuned by electric current and reaction time, and exhibits broad substrate scope and high functional group tolerance even to reduction-sensitive moieties. Initial mechanistic studies suggest that the approach heavily relies on the utilization of amines (e.g., i-Pr 2 NH), which are able to generate α-aminoalkyl radicals. This protocol provides an efficient route for the cleavage of C-O bonds under mild conditions with high chemoselectivity.
Who reads Electroselective and Controlled Reduction of Cyclic Imides to Hydroxylactams and Lactams?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Ya Bai; Lingling Shi; Lianyou Zheng; Shulin Ning; Xin Che; Zhuoqi Zhang; Jinbao Xiang
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)