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Activation and deactivation properties of rat brain K+ channels of the Shaker-related subfamily by Alessandro Bertoli; Oscar Moran; Franco Conti is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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We studied the activation properties of members of the Shaker-related subfamily of voltage-gated K ÷ channels cloned from rat brain and expressed in Xenopus oocytes. We find that Kvl.1, Kvl.4, Kvl.5, and Kvl.6 have similar activation and deactivation kinetics. The K ÷ currents produced by step depolarisations increase with a sigmoidal time course that can be described by a delay and by the derivative of the current at the inflection point. The delay tends to zero and the logarithmic derivative seems to approach a finite value at large positive voltages, but these asymptotic values are not yet reached at +80 inV. Deactivation of the currents upon stepping to negative membrane potentials below -60 mV is fairly well described by a single exponential. The decrease of the deactivation time constant at increasingly negative voltages tends to become less steep, indicating that this parameter also has a finite limiting value, which is not yet reached, however, at -160 mV. The various clones studied have very similar voltage dependencies of activation with halfactivation voltages ranging between -50 and -11 mV and maximum steepness yielding an e-fold change for voltage increments between 3.

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Author

Alessandro Bertoli; Oscar Moran; Franco Conti

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 1432-1017)

Published

1994

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)