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Vasoactive Intestinal Peptide Causes Marked Cephalic Vasodilation, but does not Induce Migraine by A Rahmann; T Wienecke; JM Hansen; J Fahrenkrug; J Olesen; M Ashina is a Medicine article available to read on EtoBox.

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We hypothesized that intravenous infusion of the parasympathetic transmitter, vasoactive intestinal peptide (VIP), might induce migraine attacks in migraineurs. Twelve patients with migraine without aura were allocated to receive 8 pmol kg^-1^min^-1^VIP or placebo in a randomized, double-blind crossover study. Headache was scored on a verbal rating scale (VRS), mean blood flow velocity in the middle cerebral artery ( V~mean mca~) was measured by transcranial Doppler ultrasonography, and diameter of the superficial temporal artery (STA) by high-frequency ultrasound. None of the subjects reported a migraine attack after VIP infusion. VIP induced a mild immediate headache (maximum 2 on VRS) compared with placebo ( P = 0.005). Three patients reported delayed headache (3-11 h after infusion) after VIP and two after placebo ( P = 0.89). V~mean mca~decreased (16.3 ± 5.9%) and diameter of STA increased significantly after VIP (45.9 ± 13.9%). VIP mediates a marked dilation of cranial arteries, but does not trigger migraine attacks in migraineurs. These data provide further evidence against a purely vascular origin of migraine.

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Author

A Rahmann; T Wienecke; JM Hansen; J Fahrenkrug; J Olesen; M Ashina

Publisher

SAGE Publications

Published

2008

Language

EN

Field

Medicine (Health Sciences)